Holomonitor
HoloMonitor® Live Cell Imaging System
HoloMonitor®: An Innovative System for Live Cell Imaging
HoloMonitor®, developed by Phase Holographic Imaging (PHI), is a live cell imaging system that enables non-invasive, real-time analysis of living cells within standard CO₂ incubators.
By utilizing digital holography, HoloMonitor captures detailed 3D images of cells without requiring any dyes or markers. This preserves cell integrity and enables long-term studies.
Its compact design allows easy placement into standard incubators, ensuring stable and physiologically suitable conditions for cell cultures. The accompanying App Suite software provides automated cell imaging and analysis capabilities, offering insights into cell morphology, motility, proliferation, and more. An optional fluorescence module can also be integrated for advanced analysis of cellular behavior.
HoloMonitor offers a user-friendly interface and workflow, making it a valuable tool in cancer research, stem cell studies, drug development, and cytotoxicity testing.
🔗 For more information, visit PHI’s official website: phiab.com
HoloMonitor®: Non-Invasive Live Cell Analysis
Discover the Full Story of Your Cells
HoloMonitor® enables unique, label-free live cell analysis by observing cells in their natural environment within a standard incubator.
Key Features:
No dyes or markers required; cells are studied in their natural state.
Real-time and long-term monitoring of cell behavior.
Accurate and quantitative analysis via QPI technology.
HoloMonitor® Live Cell Imaging System
Compact and User-Friendly:
A minimal-intervention cell imaging system that integrates seamlessly into standard CO₂ incubators without the need for labeling.
Gentle Monitoring via Digital Holography:
Uses low-energy lasers to perform natural, label-free imaging without harming the cells.
24/7 Real-Time Data:
Continuously tracks critical cellular behaviors such as morphology, migration, division, motility, and cell death.
QPI Technology: Observe Cells Without Labels
What is QPI?
Quantitative Phase Imaging (QPI) is a microscopy technology that uses the refractive index of cells to generate high-contrast images without the need for dyes or labels.
Advantages of QPI Technology:
Label-free and non-invasive observation
Enables real-time and long-term tracking
Operates with low light intensity, preserving natural conditions
Provides numerical data on cell mass, volume, density, and internal structures
Research Areas Supported by HoloMonitor®
HoloMonitor® offers innovative solutions for long-term, label-free observation of cells in their natural environment. QPI technology enables highly sensitive and quantitative cell data acquisition.
Primary Applications:
✅ Cancer Research – Analysis of cell growth, metastasis, and drug sensitivity
✅ Stem Cell Studies – Monitoring differentiation, migration, and cell viability
✅ Drug Development – Cytotoxicity testing and drug-cell interaction analysis
✅ Immunology & Infection – Studying immune cell and pathogen interactions
✅ Neurodegenerative Diseases – Monitoring neuron growth, stress responses, and drug testing
✅ Tissue Engineering – Observing cell interactions with biomaterials and artificial scaffolds
Advanced Technology & User-Friendly Software
Digital Holography:
Allows prolonged observation with low-energy light, ensuring non-invasive monitoring.
App Suite Software:
Guides users through every step from imaging to analysis via an intuitive interface.
Automated Cell Tracking & Analysis:
Quantitatively evaluates cell growth, morphology, and motility.
HoloMonitor® App Suite: A Powerful Tool for Cell Analysis
The App Suite software offers a comprehensive platform for analyzing live cell growth, motility, and proliferation. With its label-free and non-invasive imaging technology, researchers can monitor cell behavior in real time and generate reliable quantitative data.
Tracking cell volume during mitosis
Cell quality control results
Cell motility visualizations
Automated proliferation analysis
HoloMonitor® Hardware
The HoloMonitor® system is engineered for non-invasive monitoring of cells in their natural environment. It comprises several integrated components:
Imaging Unit:
The main compact microscope placed inside the incubator for continuous monitoring.
Motorized Stage:
Supports various culture dishes and allows imaging of multiple locations automatically.
Laser Module:
Mounted outside the incubator, this provides a low-energy laser for label-free holographic imaging.
Fluorescence Module (Optional):
Adds green fluorescence to complement holographic imaging for more detailed cellular insights.
User Feedback & Success Stories
Dr. Alain Geloen: “HoloMonitor® is an excellent tool that provides clean 3D images of cells non-invasively. The software is user-friendly and delivers unique insights into cell morphology.”
HoloMonitor®: A Next-Gen Solution for Cell Imaging & Analysis
HoloMonitor® is a cutting-edge live cell imaging system designed for label-free and non-invasive observation. With its integrated imaging unit, motorized stage, laser module, and optional fluorescence module, it enables researchers to conduct high-precision cell analysis.